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歐威志

 

 

 

 

歐威志　 助理教授  

學歷 

國立清華大學  生命科學研究所  博士

中山醫學院     醫學研究所     碩士

中山醫學院    醫事技術學系    學士

專長 

病毒學、分子生物學、基因工程學、微生物學

任教科目 

微生物學、免疫學、病毒學、臨床微生物學

研究成果 

(A) SCI 期刊論文

  1. J Gen Virol. 2011 Nov;92(Pt 11):2637-45. Epub 2011 Jul 13. Phosphorylation of Ser-80 of VP1 and Ser-254 of VP2 is essential for human BK virus propagation in tissue culture.  Chen PL, Hsu PH, Fang CY, Chang CF, Ou WC, Wang M, Chang D*. (SCI)
  2. Chang CF, Wang M, Ou WC, Chen PL, Shen CH, Lin PY, Fang CY, Chang D. Human JC virus-like particles as a gene delivery vector. Expert Opin Biol Ther. 2011 Sep;11(9):1169-75. (SCI)
  3. Chen PL, Hsu PH, Fang CY, Chang CF, Ou WC, Wang M, Chang D. (2011) Phosphorylation of Ser-80 on VP1 and Ser-254 on VP2 are essential for human BK virus propagation in tissue culture. J Gen Virol. [Epub ahead of print]. (SCI)
  4. Chen LS, Wang M, Ou WC, Fung CY, Chen PL, Chang CF, Huang WS, Wang JY, Lin PY, Chang D. (2010) Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model. Gene Ther. 2010 Aug;17(8):1033-41 (SCI)
  5. M. WANG, T.H. TSOU, L.S. CHEN, W.-C. OU, P.L. CHEN, C.F. CHANG, C.Y.FUNG, and D. CHANG. (2005) Inhibition of Simian Virus 40 Large Tumor Antigen Expression in Human Fetal Glial Cells by an Antisense Oligodeoxynucleotide Delivered by the JC Virus-Like Particle. HUMAN GENE THERAPY 15:1077–1090 (SCI)
  6. Fang CY, Chen HY, Wang M, Chen PL, Chang CF, Chen LS, Shen CH, Ou WC, Tsai MD, Hsu PH, Chang D. Global analysis of modifications of the human BK virus structural proteins by LC-MS/MS. Virology. 2010 Jun 20;402(1):164-76. (SCI)
  7. Huang, Y.-L., M.-L. Wang, W.-C. Ou, and D.C. Chang. 2003. Analysis of DNA binding activity of the JCV minor capsid protein VP2. Journal of NeuroVirology. 9:21-4. (SCI)
  8. Ou, W.-C., L.-H. Chen, M.-L. Wang, T.-H. Hseu and D.C. Chang. 2001. Analysis of minimal sequences on JC virus VP1 required for capsid assembly. Journal of NeuroVirology. 7:298-301. (SCI)
  9. Chen, P.-L. M.-L. Wang, W.-C. Ou, C.-K. Lii, and D.C. Chang. 2001. Disulfide bonds stabilize JC virus capsid-like structure by protecting calcium ions from chelation. FEBS Letter. 500:109-113. (SCI)
  10. Ou, W.-C., M. Wang, H. Chang, G. J. Tasy, T.-H. Hseu and D.C. Chang. 2001. Identification of a DNA encapsidation sequence for human polyomavirus pseudovirion formation. Journal of Medical Virology. 64:366-373. (SCI)
  11. Wang, M.-L., R.-T. Tsai, W.-C. Ou, C.-K. Lin, G. J. Tsay, H. Chang and D.C. Chang. 2000. Treatment with cytotoxic immunosuppression agents increases urinary excretion of JCV in patients with autoimmune disease.” Journal of Medical Virology. 62:505-510. (SCI)
  12. Wang, M-L, T.-Y. Tzeng, C.-Y. Fung, W.-C. Ou, R.-T. Tsai, C.-H. Chen and D.C. Chang. 1999. Human anti-JC virus serum reacts with native but not denatured JC virus major capsid protein VP1. Journal of Virological Methods. 78:171-176. (SCI)
  13. Ou, W.-C., M.-L. Wang, C-Y. Fung, R.-T. Tsai, P-C. Chao, T.-H. Hseu, and D.C. Chang . 1999. The major capsid protein VP1 of human JCV expressed in E. coli is able to self-assemble into a capsid-like particle and deliver exogenous DNA into human kidney cells. Journal of General Virology. 80:39-46. (SCI)
  14. Tsai, R.-T., M.L. Wang, W.-C. Ou, Y.-L. Lee, S.-Y. Li, C.-Y. Fung, Y.-L. Huang, T.-Y. Tzeng, and D.C. Chang. 1997. Viruria incidence of JC virus is higher than that of BK virus in Taiwan. Journal of Medical Virology. 52:253-257. (SCI)
  15. Chang, D.C., C-Y. Fung, W-C. Ou, P-C. Chao, S-Y. Li, M-L Wang, Y-L. Huang, T-Y. Tzeng, and R.-T. Tsai. 1997. Self assembly of the JC virus major capsid protein VP1 expressed in insect cells. Journal of General Virology. 78:1435-1439. (SCI)
  16. Ou, W.-C., R.-T. Tsai, M.-L. Wang, C-Y. Fung, T.-H. Hseu, and D.C. Chang . 1997. Genomic cloning and sequence analysis of Taiwan-3 human polyomavirus JC virus. Journal of The Formosan Medical Association. 96:511-516. (SCI)
  17. Chang, D.C., W-C. Ou, K.-K. Liao, M-L Wang, and C-Y. Fung. 1996. "Cloning, Expressing and purification of the recombinant polyomavirus VP1 and characterization of its DNA binding domain. The Chung Shan Medical Journal. 7:1-12.  (SCI)
  18. Chang, D.C., Z-M., Liou, W-C. Ou, R.-T. Tsai, K-Z. Wang, M-L Wang, and C-Y. Fung. 1996. Production of the antigen and the antibody of the JC virus major capsid protein VP1. Journal of Virological Methods. 59:177-187. (SCI)
  19. Chang, D.C., M-L Wang, W-C. Ou, R.-T. Tsai, C.-Y. Fung, and Y.-J. Hwang. 1996. A simple method to detect human polyomavirus DNA in urine by polymerase chain reaction. Journal of Virological Methods. 58:131-136. (SCI)
  20. Chang, D.C., R-T. Tsai, M-L Wang, and W-C. Ou. 1996. Different genotypes of human polyomaviruses found in patients with autoimmune diseases in Taiwan. Journal of Medical Virology. 48:204-209 . (SCI)
  21. Chang, D.C., M-L Wang, W-C. Ou, M-S. Lee, H-N. Ho, and R-T. Tsai. 1996. Genotypes of human polyomaviruses in urine samples of pregnant individuals in Taiwan. Journal of Medical Virology. 48:95-101. (SCI)

(B) 研討會論文

  1. Chia-Ju Yang, Pei-Lain Chen, Yi-Ju Chen, Wei-Chih Ou: BK Virus Minor Capsid Proteins Vp2 and Vp3 Are Essential for Virus Propagation. 第二十四屆生物醫學聯合學術年會, Taipei, 2009.
  2. Yi-Ju Chen, Pei-Lain Chen, Wei-Chih Ou: Cys-9, Cys-49, Cys-87, Cys-104 and Cys-207 of BK virus VP1 are essential in the formation of infectious virions. 第二十五屆生物醫學聯合學術年會, Taipei, 2010.