跳到主要內容區
  1. 首頁
  2. 專任師資
  3. 助理教授
  4. 林庭伊

林庭伊

林庭伊

學歷: 中山醫學大學 生化暨生物科技研究所 博士

聯絡資訊

辦公室: 9607A

E-mail: 108928@ctust.edu.tw

研究專長: 抗癌與抗病毒藥物開發及作用機轉之探討、分子診斷與精準醫療檢測系統之開發

任教科目: 臨床病毒學、細胞分子生物學、生物化學實驗、微生物學實驗

研究成果:

  1. SCI期刊論文:
  1. Swain S, Lin TY, Chou IH, Liu SC, Bikash C. Mallick, Lin HY, Huang CH. Photoactive nanocatalysts as DTT-assisted BSA-AuNCs with enhanced oxidase-mimicking ability for sensitive fluorometric detection of antioxidants. Journal of Nanobiotechnology. IF=12.6 Rank: 3.5% (5/143) (SCI).
  2. Lee PJ, Sui YH, Liu TT, Tsang NM, Huang CH, Lin TY, Chang KP, Liu SC. Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPa signaling in fibroblasts. J Exp Clin Cancer Res. 2022, 41: 254-276. IF= 12.8. Rank: 6.6% (21/318) (SCI).
  3. Akbali B, Yagmurcukardes M, Peeters F, Lin HY, Lin TY, Chen WH, Maher S, Chen TY, Huang CH*. Determining Molecular Orientation on Metal Nanoparticle Surface Through Surface-Enhanced Raman Spectroscopy and Density Functional Theory Simulations. J. Phys. Chem. 2021, 125:16289. IF= 4.6. Rank: 41.5% (143/345) (SCI).
  4. Yang CC, Hu HS, Lin HM, Wu PS, Wu RH, Tian JN, Wu SH, Tsou LK, Song JS, Chen HW, Chern JH, Chen CT, Yueh A*. A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses. Antiviral Res. 2019, 172:104636. IF= 4.0. Rank: 3.0% (11/361) (SCI).
  5. Lin HM, Wu PS, Hu HS, Chang WC, Wu RH, Tian JN, Chern JH, Yueh A. Development of robust genotype 1a hepatitis C replicons harboring adaptive mutations for facilitating the antiviral drug discovery and study of virus replication. J Virol Methods. 2018, 259:10-17. IF= 2.62. Rank: 66.1% (111/168) (SCI).
  6. Yang CC, Tsai MH, Hu HS, Pu SY, Wu RH, Wu SH, Lin HM, Song JS, Chao YS, Yueh A*. Characterization of an efficient Dengue virus replicon for development of assays of discovery of small molecules against dengue virus. Antiviral Res. 2013, 98(2):228-41. IF= 4.6. Rank: 3.0% (11/361) (SCI).
  7. Lin HM, Wang JC, Hu HS, Wu PS, Yang CC, Wang WH, Wu SY, Hsu TA, Jiaang WT, Chao YS, Yeh TK, Chern JH, Yueh A*. Resistance studies of a di-thiazol analogue, DBPR110, as a potential Hepatitis C virus NS5A inhibitor in replicon systems. Antimicrob Agents Chemother. 2013, 57(2):723-33. IF= 4.5. Rank: 10.2% (37/361) (SCI).
  8. Lin HM, Wang JC, Hu HS, Wu PS, Yang CC, Wu CP, Pu SY, Hsu TA, Jiaang WT, Chao YS, Chern JH, Yeh TK, Yueh A*. Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor. Antimicrob Agents Chemother. 2012, 56(1):44-53. IF= 4.5. Rank: 10.2% (37/361) (SCI).
  9. Pu SY, Wu RH, Yang CC, Jao TM, Tsai MH, Wang JC, Lin HM, Chao YS, Yueh A*. Successful propagation of flavivirus infectious cDNAs by a novel method to reduce the cryptic bacterial promoter activity of virus genomes. J Virol. 2011, 85(6):2927-41. IF= 6.549. Rank: 21.1% (8/38) (SCI).
  10. Chen M, Kuo HH, Huang YC, Ke YY, Chang SP, Chen CP, Lee DJ, Lee ML, Lee MH, Chen TH, Chen CH, Lin HM, Liu CS, Ma GC*. A case of restrictive dermopathy with complete chorioamniotic membrane separation caused by a novel homozygous nonsense mutation in the ZMPSTE24 gene. Am J Med Genet A. 2009, 149A(7):1550-4. IF= 2.578. Rank: 63.9% (122/191) (SCI).
  11. Sun MJ, Cheng WL, Wei YH, Kuo CL, Sun S, Tsai HD, Lin HM*, Liu CS*. Low copy number and high 4977 deletion of mitochondrial DNA in uterosacral ligaments are associated with pelvic organ prolapse progression. Int Urogynecol J Pelvic Floor Dysfunct. 2009, 20(7):867-72. (*corresponding author) IF= 1.911. Rank: 26.4% (14/53) (SCI).
  12. Lin HM, Tseng HC, Wang CJ, Lin JJ, Lo CW, Chou FP*. Hepatoprotective effects of Solanum nigrum Linn extract against CCl(4)-induced oxidative damage in rats. Chem Biol Interact. 2008, 15;171(3):283-93. IF= 5.2. Rank: 10% (10/100) (SCI).
  13. Lo CW, Huang HP, Lin HM, Chien CT, Wang CJ*. Effect of Hibiscus anthocyanins-rich extract induces apoptosis of proliferating smooth muscle cell via activation of P38 MAPK and p53 pathway. Mol Nutr Food Res. 2007, 51(12):1452-60. IF= 4.7. Rank: 14.6% (21/144) (SCI).
  14. Lin HM, Tseng HC, Wang CJ, Chyau CC, Liao KK, Peng PL, Chou FP*. Induction of autophagy and apoptosis by the extract of Solanum nigrum Linn in HepG2 cells. J Agric Food Chem. 2007, 2;55(9):3620-8. IF= 6.2. Rank: 8.0% (6/75) (SCI).

  1. 研討會論文:
  1. Chou IH, Tsai EP, Swain S, Lin TY, Lin YP, Lin HY, Huang CH. Graphene oxide and morphology-controlled dendritic silver nanoparticle with facile filter paper as a SERS-active substrate for the detection of interleukin 6. The International Society for Optics and Photonics, SPIE Photonics West 2025 in San Francisco in January 2025.
  2. Ting YJ, Chou IH, Tsai EP, Swain S, Lin TY, Huang CH. Single-molecule DNA diagnostics enhanced by image processing and digital PCR on track-etched membrane. The International Society for Optics and Photonics, SPIE Photonics West 2025 in San Francisco in January 2025.
  3. Lin YP, Chou IH, Tsai EP, Swain S, Lin TY, Ting YJ, Lin HY, Huang CH. Highly ordered self-assembled monolayer of nanoparticles film as a SERS-active substrate for quantitative acute myocardial infarction diagnosis. The International Society for Optics and Photonics, SPIE Photonics West 2025 in San Francisco in January 2025.
  4. Hsu PW, Chen YC, Liu YH, Wei ZY, Chen CH, Ho LH, HW, Yao, Lin TY, Chou IH, Chung YH, Lan WC, Yen TY, Chueh HE, Huang CH, Lin HY. Integrated aiot digital bead-based sensor for molecular-fingerprint profiling of extracellular vesicles. The 18th International Symposium on Solid Oxide Fuel Cells at USA in April 2023.
  5. Chueh HE, Liao ZY, Lin TY, Lei SY, Lin HY and Huang CH, "A Portable Microfluidic Immuno-biochip Platform for Oral Cancer Biomarker Detection, IEEE International Conference on Digital Health at USA in 2021.
  6. Lin YP, Chou IH, Tsai EP, Swain S, Lin TY, Lin HY, Huang CH. Fabrication of Highly Ordered SERS-Active Substrate Based on Self-Assembled Monolayer of Nanoparticles for Acute Myocardial Infarction Diagnosis.

International conference on smart sensors at Taiwan in July 2024.

  1. Chou IH, Swain S, Lin TY, Wu YD, Huang CH, Lin HY. Biodegradable Polymeric Coatings for Surface Modification of Magnesium Alloy Vascular Scaffolds. Annual Symposium of Taiwanese Society of Biomedical Engineering, Project Report of National Science and Technology Council in Taiwan 2023 in November 2023. Outstanding Student Paper Award.
  2. Lin TY, Chou IH, Lin XJ, Lin HY, Huang CH. Underwater surface modification of hydrogel contact lenses for superhydrophilicity and increased biocompatibility. Annual Symposium of Taiwanese Society of Biomedical Engineering, Project Report of National Science and Technology Council in Taiwan 2023 in November 2023.
  3. Chen YJ, Lin TY, Huang CH. Integrative analysis of breast cancer in TCGA for identification of potential microRNA diagnostic panel and uncovering oncogenic role. Annual Symposium of Taiwanese Society of Biomedical Engineering, Project Report of National Science and Technology Council in Taiwan 2023 in November 2023. Oral competition outstanding award.
  4. Ting YJ, Chou IH, Swain S, Lin, YP, Lin TY, Huang CH. Track-Etched Membrane-Based Single-Molecule DNA Diagnostics with Digital PCR. Annual Symposium of Taiwanese Society of Biomedical Engineering, Project Report of National Science and Technology Council in Taiwan 2023 in November 2023.
  5. Swain S, Lin TY, Chueh HE, Chou IH, Ting YJ, Lin HY, Huang CH “Photo-Responsive Nanozyme Sensor: Harnessing Emissive Oxidase-mimic Nanozyme for On-Site Antioxidant Detection in Human Saliva”, The 6th International Symposium of Materials on Regenerative Medicine (ISOMRM) and Annual Meeting of Biomaterials and Controlled Releases Society in Taiwan (BCRS) in September 2023.
  6. Swain S, Lin TY, Chueh HE, Chou IH, Lin HY, Huang CH. Photo-activated oxidase-mimic nanozyme based biosensor for on-site antioxidant detection from human saliva. International conference on smart sensors at Taiwan in June 2023.
  7. Swain S, Lin TY, Chueh HE, Chou IH, Ting YJ, Lin HY, Huang CH. Photo-resposive emissive oxidase-like nanozyme based onsite antioxidant detection sencor from human saliva. 2023 Annual meeting of the physical society of Taiwan at Taiwan in January 2023.
  8. Swain S, Lin TY, Chueh HE, Chou IH, Lin HY, Huang CH. Photo-resposive oxidase-like nanozyme based sensor for assessment of the total antioxidant capacity from human saliva. 2022 Optics & Photonics Taiwan international conference at Taiwan in December 2022.
  9. Lin TY, Chou IH, Chueh HE, Swain S, Lin HY, Huang CH. Surface modification of hydrogel contact lenses underwater for superhydrophilicity with improved biocompatibility. The 5th global conference on biomedical engineering at Taiwan in December 2022.
  10. Swain S, Lin TY, Chueh HE, Chou IH, Lin HY, Huang CH. Photo-regulated emissive oxidase-like nanozyme based sensor for evaluation of the total antioxidant capacity from human saliva. The 5th global conference on biomedical engineering at Taiwan in December 2022.
  11. Chen WY, Lin TY, Chueh HE, Chou IH, Swain S, Lin HY, Huang CH. Synthesis of functional titanium implants coatings with hierarchical polymers for preventing infection and promoting osseointegration. The 5th global conference on biomedical engineering at Taiwan in December 2022.
  12. Hsieh YC, Lin TY, Chou IH, Chueh HE, Swain S, Lin HY, Huang CH. Biodegradable polymeric coating on Magnesium alloy stents enhances corrosion resistance and thromboresistance. The 5th global conference on biomedical engineering at Taiwan in December 2022.
  13. Wu CY, Lin TY, Chou IH, Chueh HE, Swain S, Lin HY, Huang CH. Biocompatible polysaccharide-based anti-bacterial coating for Clear Overlay Appliances. The 5th global conference on biomedical engineering at Taiwan in December 2022.Lin TY, Chou IH, Chueh HE, Swain S, Lin HY, Huang CH. Surface modification of hydrogel contact lenses for enhancing surface properties and increasing the biocompatibility. International conference on smart sensors at Taiwan in October 2022.
  14. Swain S, Lin TY, Chueh HE, Chou IH, Lin HY, Huang CH. Emissive oxidase-like nanozyme based sensor for assessing the total antioxidant capacity of human saliva. International conference on smart sensors at Taiwan in October 2022.
  15. Lin TY, Chou IH, Chueh HE, Swain S, Lin HY, Huang CH. Surface modification of hydrogel contact lenses for enhancing surface characteristics. Annual meeting of biomaterials and controlled release society at Taiwan in September 2022.
  16. Chen WY, Lin TY, Chueh HE, Chou IH, Swain S, Lin HY, Huang CH. Synthesis of functional titanium implants coatings with hierarchical polymers for infection prevention and promoting osseointegration. Annual meeting of biomaterials and controlled release society at Taiwan in September 2022.
  17. Swain S, Lin TY, Chueh HE, Chou IH, Lin HY, Huang CH. Emissive oxidase-like nanozyme based portable micrfluidic detection system for evaluation of total antioxidant capacity from human saliva. Annual meeting of biomaterials and controlled release society at Taiwan in September 2022.
  18. Hsieh YC, Lin TY, Chou IH, Chueh HE, Swain S, Lin HY, Huang CH. Synthesize biodegradable polymeric coatings for controlling corrosion rate an thromboresistance of magnesium alloy stents. Annual meeting of biomaterials and controlled release society at Taiwan in September 2022.
  19. Wu CY, Lin TY, Chou IH, Chueh HE, Swain S, Lin HY, Huang CH. Polysaccharide-based layer-by-layer coating with antibacterial effect and improved durability for clear overlay appliances in dentist. Annual meeting of biomaterials and controlled release society at Taiwan in September 2022.
  20. Chou IH, Lin TY, Swain S, Chueh HE, Lin HY, Huang CH. Highly efficient surface modification of polymer substrate using functional silatrane for biomedical applications. Annual meeting of biomaterials and controlled release society at Taiwan in September 2022.
  21. Chen YC, Liao ZY, Lin TY, Lin HY, Huang CH. Portable optical immunoassay platform for instant acute coronary artery disease detection. Annual meeting of Taiwanese society of biomedical engineering at Taiwan in November 2021.
  22. Liao ZY, Lin TY, Lei HY, Lin HY, The IoT-based optical detection platform for diagnosis of oral squamous cell carcinoma. International conference on smart sensors at Taiwan in October 2021.
  23. Chueh HE, Chen YC, Chou IH, Liao ZY, Yang YJ, Lin TY, Lin HY, Huang CH. An oral cancer biomarker detection system using portable optical microfluidic immunoassay platform. Annual meeting of biomaterials and controlled release society at Taiwan in September 2021.
  24. Chen YC, Chou IH, Liao ZY, Chueh HE, Lin TY, Lin HY, Huang CH. The IoT optical immunoassay platform for instant acute coronary artery disease detection. Annual meeting of biomaterials and controlled release society at Taiwan in September 2021.
  25. Liao ZY, Chueh HE, Chou IH, Yang YJ, Chen YC, Lin TY, Lin HY, Huang CH Detection of biomolecules by highly sensitive SERS-active substrates based on reproducible AgNP/AAO arrays. Annual meeting of biomaterials and controlled release society at Taiwan in September 2021.
  26. Chueh HE, Liao ZY, Lin TY, Lei HY, Lin HY, Huang CH. A Portable Microfluidic Immuno-biochip Platform for Oral Cancer Biomarker Detection. IEEE International conference on digital health at Taiwan in September 2021.
  27. Liao ZY, Lin TY, Lei HY, Lin HY, Huang CH. The IoT-based optical detection platform for diagnosis of oral squamous cell carcinoma. International conference on smart sensors at Taiwan in October 2021.
  28. Yang CC, Hu HS, Lin HM, Wu PS, Wu RH, Tian JN, Wu SH, Tsou LK, Song JS, Chen HW, Chern JH, Chen CT, Yueh A*. A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses. Symposium on New Emerging Mosquito-Borne Disease and Vectors at Taiwan in November 2019.
  29. Yang CC, Hu HS, Lin HM, Wu PS, Wu RH, Tian JN, Wu SH, Tsou LK, Song JS, Chen HW, Chern JH, Chen CT, Yueh A*. A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses. Symposium on New Emerging Mosquito-Borne Disease and Vectors at Taiwan in November 2019.
  30. Yang CC, Hu HS, Lin HM, Wu PS, Wu RH, Tian JN, Wu SH, Tsou LK, Song JS, Chen HW, Chern JH, Chen CT, Yueh A*. A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses. 31th International Conference on Antiviral Research at Portugol in June 2018.
  31. Lin HM, Wu PS, Hu HS, Lee CC, Lee YC, Hsu SJ, Tian YW, Chern JH*, Yueh A*. Characterization of a Pre-clinical Candidate Compound, DBPR111, As a Potential Hepatitis C Virus NS5A Inhibitor. NHRI Research Day at Taiwan in March 2014.
  32. Lin HM, Wang JC, Hu HS, Wu PS, Hsu TA, Chao YS, Yeh TK, Chern JH, Yueh A*. In vitro resistance studies of a di-thiazol analogue, DBPR110, as a potent Hepatitis C virus NS5A inhibitor. NHRI Research Day at Taiwan in March 2013.
  33. Lin HM, Wang JC, Hu HS, Wu PS, Yang CC, Wu CP, Pu SY, Hsu TA, Jiaang WT, Chao YS, Chern JH, Yeh TK, Yueh A*. Resistance Analysis and Characterization of a Thiazole Analogue, BP008, as a potent Hepatitis C Virus NS5A Inhibitor. 25th International Conference on Antiviral Research at Japan in April 2012.
  34. Lin HM, Wang JC, Hu HS, Wu PS, Hsu TA, Jiaang WT, Chao YS, Chern JH, Yeh TK, Yueh A*. Resistance Analyses and Characterization of a Thiazole Analogue, BP008, as a potent Hepatitis C Virus NS5A Inhibitor. NHRI Research Day at Taiwan in March 2011.
  35. Tsai TL, Lin HM, Kuo CL, Lin TT, Wei YH, Liu CS*. The correlation between common carotid arteries intima-media thickness and oxidative damage-, copy number of mitochondrial DNA in leukocytes. Annul Meeting of Neurology at Taiwan in May 2009.
  36. Huang CH, Lin HM, Lin TT, Kuo CL, Liu CS. Low copy number of mitochondrial DNA is associated with progression of metabolic syndrome. Thirty Nine Annul Meeting of Cardiology at Taiwan in May 2009.
  37. Lin HM, Lin TT, Kuo CL, Liu CS*. Oxidative damage of mitochondrial DNA in leukocytes is associated with progression of metabolic syndrome. XV International Symposium on Atherosclerosis at USA in June 2009.
  38. Liu CS, Huang CH, Chen WL, Lin HM*. A low mitochondrial DNA copy number of leukocytes are associated with progression of metabolic syndrome. XV International Symposium on Atherosclerosis at USA in June 2009.
  39. Lin HM, Lu YN, Cheng WL, Lin DT, Tsai WJ, Liu CS*. Mitochondrial DNA mutation in maternal or sporadic myoclonus epilepsy and mental retardation. Indy 2008: Setting the Pace in Mitochondrial Medicine at USA in Jun 2008.
  40. Liu CS, Cheng SD, Lan C, Lin TT, Hsu NC., Lin HM, Kuo SJ*. Multiple Somatic Mutations in Mitochondrial DNA D-Loop Region is Associated with Poor Survival in Breast Cancer. Thirteenth Annul meeting of Cancer at Taiwan in May 2008.
  41. Tseng HC, Lin HM, Liu WS, Hsin CH, Chuang CY, Chou FP*. Radiation-induced autophagy inhibits radiosensitivity of hepatoma cells. Keystone Symposia on molecular and Cellular Biology at USA in April 2007.
  42. Lin HM, Tseng HC, Chou FP*. Induction of autophagy and apoptosis by the extract of Solanum nigrum Linn in HepG2 cells. Performance Presentation, Chung Shan Medical University at Taiwan in October 2006.
  43. Huang CM, Lin HM, Tseng HC, Chou FP*. The study of the anti-cancer functions of the polyphenolic extract ofSolanum nigrum Linn. Performance Presentation, Chung Shan Medical University at Taiwan in 2006.

榮譽事項:

1. 2022 全方位血液細胞影像與生化分析系統: 經濟部智慧財產局國家發明創作獎發明獎 金牌

2. 2022 隱形眼鏡之表面修飾提升親水性與抗菌力: 經濟部智慧財產局國家發明創作獎發明獎 金牌

3. 2022 指導專題生「核桃飲食調控血糖」2022年醫工日創新醫材競賽 佳作

4. 2021 全方位血液細胞影像與生化分析系統開發:第十八屆國家新創獎 (學研新創獎)

5. 2021 全方位血液細胞影像與生化分析系統開發:國家未來科技突破獎

6. 2016  C型肝炎候選新藥開發團隊:台北生技獎銀獎

7. 2016  C型肝炎候選新藥開發團隊:經濟部智慧財產局國家發明創作獎發明獎金牌

8. 2014  C型肝炎候選新藥DBPR110研究成果:國家衛生研究院 NHRI Research Day優秀壁報論文獎

9. 2013  C型肝炎候選新藥開發團隊:國科會傑出技術移轉貢獻獎

10. 2013  C型肝炎候選新藥BP008研究成果:國家衛生研究院 NHRI Research Day優秀壁報論文獎

11. 2006 龍葵萃取物抗肝癌與機轉之探討:中山醫學大學專題計畫成果發表會 口頭報告組第一名

12. 2006 龍葵萃取物保肝功能評估之研究: 中山醫學大學專題計畫成果發表會 壁報組佳作

13. 2002 中華民國斐陶斐榮譽學會 中山醫學大學會員