陳碧蓮
陳碧蓮 副教授
學歷
國立中正大學 化學暨生化所 博士
中山醫學院 生物化學研究所 碩士
台北醫學院 醫事技術系 學士
專長
病毒學、分子生物、血液學
任教科目
血液學、臨床生化學、醫技特論
研究成果
(A) SCI 期刊論文
1. Huang CH , Chi CY, Chen YS, Chen KY, Chen PL, Chun-Hsu Yao CH*. Evaluation of proanthocyanidin-crosslinked electrospun gelatin nanofibers for drug delivering system. Materials Science and Engineering C.2012(SCI IF 2.685)
2. Liaw YC#, Chen CH#, Kuo-Hsiung KH, Fang CY, Ou WC, Chen PL, Cheng-Huang Shen CH, Lin MC, Deching Chang DC, Meilin Wang ML*. Recombined sequences between the non-coding control regions of JC and BK viruses found in the urine of a renal transplantation patient. Virus Genes. 2012. (SCI IF 1.845)
3. Fang CY, Lin PY, Ou WC, Chen PL, Shen CH, Chang DC , Wang ML*. Analysis of the size of DNA packaged by the human JC virus-like particle. Journal of Virology Method.2012, Mar ; 182(1-2):87-92.(SCI 2.011)
4. Chen PL, Hsu PH, Fang CY, Chang CF, Ou WC, Wang ML and Chang DC*. Phosphorylation of Ser-80 of VP1 and Ser-254 of VP2 is essential for human BK virus propagation in tissue culture. Journal of General Virology. 2011 Nov; 92(11), 2637–2645. (SCI; IF 3.568)
5. Chang CF, Wang ML, Fang CY, Chen PL, Wu SF, Chan MW, Chang DC. Analysis of DNA methylation in human BK virus. Virus Genes. 2011 Oct; 43(2):201-7. (SCI, IF 1.71)
6. Chang CF, Wang ML, Fang CY, Ou WC, Chen PL, Shen CH, Lin PY, Fang CY and Chang DC. Human JC virus-like particles as a gene delivery vector. Expert Opinion on Biological Therapy. 2011 Sep;11(9):1169-75.(SCI, IF 3.279)
7. Chen LS, Wang ML, Ou WC, Fung CY, Chen PL, Chang CF, Huang WS, Wang JY, Lin PY, Chang DC. Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model. Gene Therapy. 2010 Aug; 17(8), 1033–1041. (SCI, IF 4.492)
8. Fang CY, Chen HY, Wang ML, Chen PL, Chang CF, Chen LS, Shen CH, Ou WC, Tsai MD, Hsu PH, Chang DC. Global analysis of modifications of the human BK virus structural proteins by LC-MS/MS. Virology. 2010 Jun; 402(1):164-76. (SCI, IF 3.539)
9. Wang ML, Chen LS, Ou WC, Chen PL, Fung CY, Chang CF,Chang DC*. 2004. Inhibition of simian virus 40 large tumor antigen expression in human fetal glialcells by an antisense oligodeoxynucleotide delivered by the JC virus-like particle. Human Gene Therapy 15:1077-1090. (SCI 4.218)
10. Chen, P L, M. Wang ML, Ou WC, Li CK, Chen LS, Chang DC*. 2001. Disulfide bonds stabilize JC virus capsid-like structure by protecting calcium ions from chelation. FEBS Lett 500:109-13. (SCI 3.92)
11. 陳碧蓮*,黃瓊華,病毒性載體之基因治療應用及特性分析(綜論).生物醫學及檢驗雜誌,2012,第24卷,第三期.
12.黃瓊華ǂ，歐威志ǂ，李明憲1，陳奕儒，陳碧蓮* 非致病性病毒類殼體之生產與應用: 以人類多瘤性BK病毒為例,生物醫學及檢驗雜誌,2012,第24卷,第三期.
13.李明憲,廖朝財, 歐威志, 陳碧蓮, 黃瓊華,陳妤瑄,黃海義,黃鴻堅*.台灣常見兔愛美球蟲的RAPD分子鑑定.台灣獸醫學雜誌.2012.
(B) 研討會論文
1. Chen PL, Ou WC, Wang ML, Fang CY, Chang CF, Hsu PH* and Chang DC*. Global analysis the disulfide linkages of BK virus by LC/MS/MS.The 19th Symposium on Recent Advances in Cellular and Molecular Biology, Pingtung, 2011.
2. Chang CF, Fang CY, Chen PL, Wang ML, Wu SF, Chan MWY and Chang DC*. Analysis of DNA methylation in Human BK virus. The 19th Symposium on Recent Advances in Cellular and Molecular Biology, Pingtung, 2011.
3. Chen PL, Fang CY, Hsu PH, Wang ML, Chang CF, Ou WC, Chang DC*. Phosphorylation of serine 80 on Vp1 is required for BK virus replication: The 18th Symposium on Recent Advances in Cellular and Molecular Biology, Pingtung, 2010.
4. Chen YR, Ou WC＊, Chen PL＊.Cys-9, Cys-49, Cys-87, Cys-104 and Cys-207 of BK virus VP1 are essential in the formation of infectious virions. The 25th Joint Annual Conference of Biomedical Scienc, 2010.
5. Chen PL, Fang CY, Hsu PH, Wang ML, Chang CF, Ou WC, Chang DC*. Proteomic methods detect the phosphorylation of BK virus major capsid protein VP1. Taiwan Society for Mass Spectrometry Conference on Mass Spectrometry Annual Meeting, Tai-chung, 2009.