Chen,Shih Shun
Shih-Shun Chen
Job title:Professor
Research expertise:
Research interests in our laboratory are the molecular biology, pathogenesis, and vaccine development of Japanese encephalitis virus as well as the molecular mechanisms of action of potential anti-cancer agents.
Emai: sschen1@ctust.edu.tw
Office phone number:(04) 2239-1647 #7057
Education：Ph.D., Graduate Institute of Life Sciences, National Defense Medical College, Taiwan.
Courses Taught：Clinical Hematology, Clinical Serology, Biologics, Molecular Virology, and Special topics in Molecular Diagnostics
Professional Fields:Cancer Biology and Molecular Virology
Representative Publication in 5 Years
Hui-Li Lu, Shih-Shun Chen*, Wen-Tung Hsu, Yao-Cheng Lu, Chuan-Chun Lee, Tian-Shung Wu, Meng-Liang Lin*. 2016. Suppression of phospho-p85a–GTP-Rac1 lipid raft interaction by bichalcone analog attenuates cancer cell invasion. Mol Carcinog. 55:2106–2120. (co-first and co-corresponding authors)
Yao-Cheng Lu, Meng-Liang Lin, Hong-Lin Su, and Shih-Shun Chen*. 2016. ER-dependent Ca++-mediated cytosolic ROS as an effector for induction of mitochondrial apoptotic and ATM-JNK signal pathways in gallic acid-treated human oral cancer cells. Anticancer Res. 36(2): 697-705. (corresponding author)
Meng-Liang Lin*, Shih-Shun Chen, and Tian-Shung Wu. 2015. Synthetic bichalcone TSWU-BR23 induces apoptosis of human colon cancer HT-29 cells by p53-mediated mitochondrial oligomerization of BAX/BAK and lipid raft localization of CD95/FADD. Anticancer Res. 35(10):5407-16.
Meng-Liang Lin*, Shih-Shun Chen, and Sue-Hwee NG. 2015. CHM-1 suppresses formation of cell surface-associated GRP78-p85α complexes, inhibiting PI3K-AKT signaling and inducing apoptosis of human nasopharyngeal carcinoma cells. Anticancer Res. 5(10):5359-68.
Meng-Liang Lin*, Shih-Shun Chen, Ren-Yu Huang, Yao-Cheng Lu, Yu-Ren Liao, M. Vijaya Bhaskar Reddy, Chuan-Chun Lee, Tian-Shung Wu. 2014. Suppression of PI3K/Akt signaling by synthetic bichalcone analog TSWU-CD4 induces ER stress- and Bax/Bak-mediated apoptosis of cancer cells. Apoptosis Nov. 19(11):1637-53.
Meng-Liang Lin, Yao-Cheng Lu, Hung-Yi Chen, Chuan-Chun Lee, Jing-Gung Chung, and Shih-Shun Chen*. 2014. Suppressing the formation of lipid raft-associated Rac1/PI3K/Akt signaling complexes by curcumin inhibits SDF-1a-induced invasion of human esophageal carcinoma cells. Mol Carcinog. 53(5):360-379 (SCI, Impact factor:4.722, (corresponding author)