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分類清單
何杏棻(系主任)

 

何杏棻 教授 兼系主任 (Tsing-Fen, Ho)

學歷 

國立中興大學 生命科學系生物科技組博士

國立陽明大學 神經科學研究所碩士

台北醫學大學 醫學檢驗生物技術系學士

專長 

生命科學、血液、毒理學 

任教科目 

生命科學、血庫、研究方法含實驗

研究成果目錄(Corresponding author *

(A) 期刊論文

  1. Ting-Ting Li, Ching-Wen Lou, An-Pang Chen, Mong-Chuan Lee, Tsing-Fen Ho, Yueh-Sheng Chen, Jia-Horng Lin. Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds. Materials. 2016; 9, 793; doi:10.3390/ma9090793  (SCI; IF 2.728)
  2. Jia-Horng Lin, An-Pang Chen, Ting-Ting Li, Tsing Fen Ho, Mei-Chen Lin, Ching Wen Lou. Preparation technique and antibacterial evaluation of high-absorbent composite fabrics. Journal of Industrial Textiles 2016; 45, 915-929. (SCI; IF 1.2; Ranking: 4/22 (top 18%; Materials Science)
  3. Tsing-Fen Ho, Chia-Che Chang. A promising “TRAIL” of tanshinones for cancer therapy. Biomedicine 2015; 5 (4), 29-35.
  4. Kai-Wei Chang#, Tsing-Fen Ho# (co-first author), Yu-Chang Lin, Cheng-Ping Kuan. Development of real-time RT-PCR assays for detection and quantification of pineapple mealybug wilt-associated viruses-1. Journal of Phytopathology; Article first published online: 16 Dec 2015. Doi: 10.1111/jph.12462. (SCI; IF 0.82; Ranking: 143/200 (top 71.5%; plant sciences)) (#co-first author)
  5. Chia-Che Chang, Cheng-Ping Kuan, Jyun-Yi Lin, Jui-Sheng Lai, Tsing-Fen Ho*. Tanshinone IIA facilitates TRAIL sensitization by up-regulating DR5 through the ROS-JNK-CHOP signaling axis in human ovarian carcinoma cell lines. Chem. Res. Toxicol. 2015; 28, 1574-1583. (SCI; IF 3.529; Ranking: 10/59 (top 16.9%; chemistry & medicinal)) (*Corresponding author)
  6. Jyun-Yi Lin, Yu-Min Ke, Jui-Sheng Lai, Tsing-Fen Ho*. Tanshinone IIA enhances the effects of TRAIL by downregulating survivin in human ovarian carcinoma cells. Phytomedicine 2015; 22, 929–938. (SCI; IF 3.126; Ranking: 2/24 (top 8.3%; integrative & complementary medicine)) (*Corresponding author)
  7. 何杏棻*.生命科學新視界—以社會議題為教學設計201411月.通識在線第五十五期,49-52頁。
  8. Chia-Che Chang, Jui-Sheng Lai, Chi-Shiuan Tsai, Song-Wei Ma, Jyun-Yi Lin, Lan-Ru Huang, Chien-Hsing Lu, En-Chih Liao, Tsing-Fen Ho*. Proapoptotic and TRAIL- sensitizing constituents isolated from Salvia militiorrhiza (Danshen). J Biosci Bioeng 2013; 116, 516-523. (SCI; IF 1.884; Ranking: 39/123 (top 31.7%; food science & technology)) (*Corresponding author)
  9. Shu-Yi Yang, Hui-Min Wang, Tai-Wen Wu, Yi-Ju Chen, Jeng-Jer Shieh, Ju-Hwa Lin, Tsing-Fen Ho, Ren-Jie Luo, Chung-Yi Chen and Chia-Che Chang. Subamolide B isolated from medicinal plant Cinnamomum subavenium induces cytotoxicity in human cutaneous squamous cell carcinoma cells through mitochondrial and CHOP-dependent cell death pathways. Evid. Based Complement. Alternat. Med., 2013 (2013). doi:10.1 155/2013/630415 (SCI; IF: 4.774; Ranking: 1/22 (top 4.5%; integrative & complementary medicine)
  10. Mu-Yun Pan, Yuh-Chiang Shen, Chien-Hsing Lu, Shu-Yi Yang, Tsing-Fen Ho, Yu-Ta Peng, Chia-Che Chang. Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines. Toxicology and Applied Pharmacology 2012; 265, 325-334. (SCI; IF: 4.447; Ranking: 10/83 (top 12 %; Toxicology))
  11. Chia-Che Chang, Wei-Chuan Chen, Tsing-Fen Ho, Ho-Shing Wu, Yu-Hong Wei: Development of natural anti-tumor drugs by microorganisms. J Biosci Bioeng 2011; 111, 501-511. (SCI; IF: 1.793; Ranking: 40/128 (top 31 %; food science & technology))
  12. Tsing-Fen Ho, Yu-Ta Peng, Show-Mei Chuang, Shin-Chang Lin, Bo-Lin Feng, Chien-Hsing Lu, Wan-Ju Yu, Jo-Shu Chang, Chia-Che Chang. Prodigiosin down-regulates survivin to facilitate paclitaxel sensitization in human breast carcinoma cell lines. Toxicology and Applied Pharmacology 2009; 235, 253-260. (SCI; IF: 4.447; Ranking: 10/83 (top 12 %; Toxicology))
  13. Tsing-Fen Ho, Chieh-Ju Ma, Chien-Hsing Lu, Yo-Ting Tsai, Yu-Hong Wei, Jo-Shu Chang, Jun-Kai Lai, Pin-Ju Cheuh, Chi-Tai Yeh, Pin-Chi Tang, Jinghua Tsai Chang, Jiunn-Liang Ko, Fu-Shing Liu, Hungchen E. Yen, and Chia-Che Chang. Undecylprodigiosin selectively induces apoptosis in human breast carcinoma cells independent of p53. Toxicology and Applied Pharmacology 2007; 225, 318-328. (SCI; IF: 4.447; Ranking: 10/83 (top 12 %; Toxicology))
  14. Tsing-Fen Ho*, Biing-Shin Yang, Yao-Teng Huang, Chin-Tun Hung. Evaluation of the use of a platelet-counting tool in plateletpheresis.Vox Sanguinis 1999;76:226-230. (SCI; IF: 2.856; Ranking: 29/68 (top 42 %; Hematology)) (獲醫檢學會臨床檢驗學術獎---血液檢測類別論文獎)
  15. Tsing-Fen Ho*, Biing-Shin Yang, Yao-Teng Huang. Evaluation of six types of hematology analyzers in Taichung blood center. J Biomed Lab Sci 1998;10:129-134.
  16. Ji-Ping Wang, Tsing-Fen Ho, Ling-Chu Chang, Chien-Chih Chen. Anti-inflammatory effect of magnolol, isolated from Magnolia officinalis, on A23187-induced pleurisy in mice. J Pharm Pharmacol 1995; 47:857-860. (SCI; IF: 2.175; Ranking: 128/261 (top 49 %; Pharmacology & Pharmacy))
  17. Ji-Ping Wang, Tsing-Fen Ho, Chung-Nan Lin, Che-Ming Teng. Effect of norathyriol, isolated from Tripterospernum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn-Schmiedeberg’s Arch Pharmacol 1994; 350-90-95. (SCI; IF: 2.647; Ranking: 101/261 (top 38 %; Pharmacology & Pharmacy))
  18. Alice-Chien Chang, Tsing-Fen Ho, Nan-Chi Chang. In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans. Biochem Biophy Res Com 1990; 172: 817-823. (SCI; IF: 2.484; Ranking: 173/290 (top 60 %; Biochemistry & Molecular Biology))

 (B) 專利

       發明專利:可提高腫瘤細胞凋亡之醫藥組合物.何杏、張嘉哲.發明第 I401080 號、中華民國專利權:自2013711日至203146日止。

 (C) 研討會論文

  1. Ju-Huei Chien, Ting-Lun Cheng, Hui-Fen Liu, Zhong-Yi Hsu, Ching-Yi Lin, Meng-Yu Kan, Shu-Cheng Liu, Chan Ping Lee, Tsing-Fen Ho*: Estimation of prevalence of acute transfusion reactions in Taiwan: a preliminary step towards to patient-focus hemovigilance. The 34th International Congress of the ISBT in 2016, Dubai.
  2. Tsing-Fen Ho*, Jyun-Yi Lin. Tanshinone IIA facilitates TRAIL sensitization through CHOP-mediated DR5 up-regulation in human ovarian cancer cells. The 8th Asia-Pacific Forum of Medical Laboratory Science in 2016, Taichung.
  3. Jyun-Yi Lin, Yu-Ting Peng, Hong-Rong Lai, Yu-Min Ke, Jui-Sheng Lai, Chia-Che Chang, Tsing-Fen Ho*. Tanshinone IIA enhances the efficacy of TRAIL against human ovary cancer cell lines. The 29th Joint Annual Conference of Biomedical Sciences, Taipei, 2014.
  4. Yu-Min Ke, Wei-Sheng Jhan, Yu-Ting Peng, Jyun-Yi Lin, Tsing-Fen Ho*. The anti-tumor effect of ethnol extracts from Danshen (Salvia milltiorrhiza) Cross-strait laboratory medicine symposium in 2013.
  5. Tsing-Fen Ho*, Cheng-Ping Kuan, Chien-Hsing Lu, Jui-Sheng Lai, Song-Wei Ma, Jyun-Yi Lin, Mu-YunPan, Shu-Yi Yang, Mei-Yan Su, Jeremy J.W. Chen, Chia-Che Chang. TIIA facilitates TRAIL sensitization through ROS-mediated CHOP up-regulation in human ovarian cancer cells. 2012  轉譯醫學基因體蛋白質體之臨床應用學術研討會, 2012.
  6. Chi-Shiuan Tsai, You-Ru Sia, Mu-YunPan, Shu-Yi Yang, Mei-YanSu, Chia-Che Chang, Tsing-Fen Ho*. Tanshinone IIA facilitates TRAIL sensitization through ROS-mediated CHOP up-regulation in human ovarian cancer cells. The 27th Joint Annual Conference of Biomedical Sciences, Taipei, 2012.
  7. Jui-Sheng Lai, Song-Wei Ma, Jyun-Yi Lin, Chi-Shiuan Tsai, Chien-Hsing Lu, Chia-Che Chang, Tsing-Fen Ho*. Study of the anti-tumor effect of active components from Salvia militiorrhiza and its apoptosis. Traditional Chinese Medicine and Alternative (Herbal) Medicine, Taichung, 2011.
  8. Yu-Ta Peng, Mu-Yun Pan, Chien-Hsing Lu, Tsing-Fen Ho, Chia-Che Chang. The anticancer agent prodigiosin up-regulates activating transcription factor 3 (ATF3) to induce apoptosis. The 26th Joint Annual Conference of Biomedical Sciences, Taipei, 2011.
  9. Bo-Lin Feng, Shin-Chang Lin, Chien-Hsing Lu, Yu-Ta Peng, Chin-Hsia Wu, Yuh-Chiang Shen, Pin-chi Tang, Tsing-Fen Ho, Jo-Shu Chang, Chia-Che Chang. Essential Role of JNK and p38 MAPK in Apoptosis Induction by the Anticancer Agent Undecylprodigiosin through TRAIL- and Mitochondria-dependent Apoptotic Pathways. The 25th Joint Annual Conference of Biomedical Sciences, Taipei, 2010.
  10. Tsing-Fen Ho, Chien-Hsing Lu, Wan-Ju Yu, Chia-Che Chang. Gene expression profiles predict prodigiosin molecular mechanism by cDNA microarray.  2010 年中區十大院校暨台中榮民總醫院合作研究計畫聯合成果發表會-榮台計畫壁報論文第二名
  11. Bo-Lin Feng, Chien-Hsing Lu, Yu-Ta Peng, Chin-Hsia Wu, Yuh-Chiang Shen, Pin-chi Tang, Tsing-Fen Ho, Jo-Shu Chang, Chia-Che Chang. Essential Role of JNK and p38 MAPK in Apoptosis Induction by the Anticancer Agent Undecylprodigiosin through TRAIL- and Mitochondria-dependent Apoptotic Pathways. 2010年台中榮總醫院與中區十大院校合作研究計畫聯合成果發表會-榮興計畫壁報論文第一名
  12. Tsing-Fen Ho, Yu-Ta Peng, Show-Mei Chuang, Shin-Chang Lin, Bo-Lin Feng, Chien-Hsing Lu, Wan-Ju Yu, Jo-Shu Chang, Chia-Che Chang. The role of survivin in prodigiosin-induced apoptosis in breast cancer cells.  2009年台中榮總醫院與中區十大院校合作研究計畫聯合成果發表會-壁報論文佳作。
  13. Tsing-Fen Ho*, Yu-Ta Peng, Show-Mei Chuang, Shin-Chang Lin, Bo-Lin Feng, Chien-Hsing Lu, Wan-Ju Yu, Jo-Shu Chang, Chia-Che Chang. Prodigiosin enhances paclitaxel drug efficacy against human breast carcinoma cell lines. The 24th Joint Annual Conference of Biomedical Sciences, Taipei, 2009.
  14. Tsing-Fen Ho, Yu-Ta Peng, Show-Mei Chuang, Shin-Chang Lin, Bo-Lin Feng, Chien-Hsing Lu, Wan-Ju Yu, Jo-Shu Chang, Chia-Che Chang. The role of survivin in prodigiosin-induced apoptosis in breast cancer cells. The 23th Joint Annual Conference of Biomedical Sciences, Taipei, 2008.
  15. Tsing-Fen Ho, Yo-Ting Tsai, Yu-Hong Wei, Jo-Shu Chang, Chieh-Ju Ma, Hungchen E. Yen, Chia-Che Chang. Selective proapoptotic effect of undecylprodigiosin on human breast cancer cell lines. The 22th Joint Annual Conference of Biomedical Sciences, Taipei, 2007.

(D) 專書及專書論文 

  1. 李意旻、何杏棻.解剖生理學實驗 ISBN 978956903734100160.智翔.1043月。
  2. 何杏棻.閱讀生命科學 ISBN 978986903733400320.智翔.1042月。
  3. 王秀雲等著.課的反身 ISBN 9789860403046.成大醫科設研究中心.1032月出版。
  4. 何杏棻.Prodiginines 抑癌活性與機制之探討.中興大學生命科學系博士學位論文.978月。
  5. 李玉菁、何杏棻、黃玉琪、陳秋媛、李意旻、阮大盛、徐玉華.人體解剖學.文京.2000 再版。
  6. 李意旻、李玉菁、何杏棻、黃玉琪、林靜瑩.解剖生理學實驗.文京.2000 再版。

近年執行計畫 (擔任計畫主持人)

  1. 研究計畫
  1. 丹參酮ⅡA 增強標靶藥物 TRAIL 之治療潛力及其分子作用機轉探討 (MOST105-2313-B-166-001) 105.8.1~106.7.31
  2. 探討丹參酮IIA 調降卵巢癌細胞內Survivin之分子機制 (CTU104-P-16) 104.5.19~104.10.15
  3. 探討吲哚化合物對結腸直腸癌抗癌作用的影響因子 (TCVGH-CTUST1037702) 103.1.1~103.12.31
  4. 探討 Survivin 蛋白於丹參酮 IIA 強化TRAIL之重要性 (TCVGH-CTUST1037704) 103.1.1~103.12.31
  5. 探討丹參酮 IIA 強化TRAIL 誘發癌細胞凋亡之效應暨其分子機制 (CTU102-P-17) 102.1.1~102.12.31
  6. 探討 Survivin 蛋白於丹參酮 IIA 誘發凋亡的重要性 (TCVGH-CTUST1027704) 102.1.1~102.12.31
  7. 台灣栽培中草藥之抗癌活性物質研究 (R100504R0050017-產學-101) 101.4.10~101.7.31
  8. 探討丹參活性成分抑癌效應暨其分子機制 (CTU99-TARI-001) 99.7.1~100.12.31
  9. 天然物 Prodiginines 抑癌活性與機制之探討 (CTU98-INS-008) 98.1.1~98.12.31
  10. 以微陣列晶片探討 prodigiosin 抑癌作用之基因群表現 (TCVGH-CTUST987718) 98.1.1~98.12.31
  11. 探討 prodigiosin 對於 TRAIL 誘發之細胞凋亡的強化效應 (CTU98-P-14) 98.1.1~98.12.31
  12. Prodigiosin 提昇 paclitaxel 抑癌效能之評測 (CTU97-PC-011) 97.8.1~98.7.31
  13. Prodigiosin 藉由 IAP 誘發乳癌細胞凋亡作用之探討 (CTU97-P-23) 97.1.1~97.12.31
  14. 探討 Survivn 在抗癌藥物 PG 誘發人類乳癌細胞株之細胞凋亡的重要性 (TCVGH-CTUST977713) 97.1.1~97.12.31
  1. 行政計畫
  1. 健康醫療分子檢測學分學程 (105教育部, 105.8-107.7)
  2. 醫檢教育的專業發展趨勢與亞太醫學檢驗科學國際研討會 (教育部區域產學合作中心, 105.3.1 -105.10.31)
  3. 醫學檢驗臨床判讀暨微電影競賽 (教育部區域產學合作中心, 104.11)
  4. 細胞診斷與分子病理技術應用學分學程 (103教育部, 103.8-105.7)
  5. 師生實務增能計畫 (103教育部, 103.6-104.5)
  6. 醫學檢驗生物技術系職涯進路與課程學習地圖建置 (100年度青輔會青貳字第1002260174-2A-15)
  7. 醫學檢驗生物技術教育評鑑研討會 (教育部醫教會醫技組) 101.4.27
  1. 課程計畫
  1. 中臺科大104改進教學計畫:系友職涯發展調查串聯課程規劃 (104-TI-04, 104.5.20~104.10.29)
  2. 中臺科大103改進教學計畫:生命科學課程實例教學參考手冊 (103.05.20-103.10.30)
  3. 教育部 102-1 公民核心能力課程改進計畫A-健康科學之公民觀點與視野 課群主持人
  4. 教育部 102-1 公民核心能力課程改進計畫A-生命科學新視界 (MOE-102-1-2-008, 102.8.1-103.1.31)
  5. 教育部 101-1 公民核心能力課程改進計畫B-生命科學新視界 (MOE-101-1-2-113, 101.8.1-102.1.31)
  6. 教育部 100-2 公民核心能力課程改進計畫B-透視生命奧秘:生命的語言 (MOE-100-2-2-075, 101.2.1-101.7.31)
  7. 教育部 100-1 公民核心能力課程改進計畫B-生命科學的奧秘 (MOE-100-1-2-086, 100.8.1-101.1.31, 獲選績優計畫)
  8. 中臺科大100改進教學計畫:檢驗所情境教學之解說建置 (100.05.26-100.10.28)
  9. 中臺科大99改進教學計畫:輸血試驗影視教材製作99.5.20~99.10.29
  10. 中臺科大98改進教學計畫:人體骨骼影視教材98.5.25~98.10.31

榮譽事項

  1. 獲選中臺科技大學院級教學優良教師 (104.8.26)
  2. 指導賴虹蓉同學參加健康科學院論文壁報第一名(104.6.5)
  3. 擔任國際期刊編審委員 (chemical research in toxicology, Life sciences, apoptosis, International Journal of Nanomedicine, ....)
  4. 何杏棻老師執行中臺科大「改進教學」編撰教材:生命科學課程實例教學參考手冊 (103.5.20-103.10.30),成果獲最高獎勵 (103.11.14)
  5. 指導林君謚同學參加中臺科大健康科學院畢業生研究成果發表競賽獲選論文壁報第二名(103.6.6)
  6. 擔任中臺科大「公民核心能力教學專業社群」召集人,獲選校內教師教學專業社群特優等(103.1.15)
  7. 通過教育部解剖學數位教材認證。(103.1)
  8. 指導彭鈺婷同學參加校內「分子診斷專題研究」競賽第一名(102.10.16)
  9. 教育部102年全國技專院校「生命科學概論」課程績優教師(教育部 102.9.14)
  10. 指導詹維昇同學參加中臺科大101-1教學助理期末成果發表競賽,獲選「優等」。(101.12.19)
  11. 指導聶廷宇許慈芳王愉雯楊琬琦同學參加課群優良短片競賽獲選第一名
  12. 指導翁莉喬黃思穎李慧純同學參加課群優良短片競賽獲選第二名
  13. 教育部 100-1 公民核心能力課程改進計畫B-生命科學的奧秘,獲選績優計畫(教育部 101.9.28)
  14. 指導蔡其烜同學參加中臺科大健康科學院畢業生研究成果發表競賽獲選論文壁報第三名(101.6.8)
  15. 指導蕭佑如同學參加校內「分子診斷專題研究」競賽第一名(100.11.30)
  16. 中臺科技大學99-1優良導師
  17. 98年度台中榮總醫院與中區十大院校合作研究計畫聯合成果發表會壁報論文第二名(100.6)
  18. 98-1擔任醫技系學會指導老師,自治性社團第一名
  19. 98-2擔任醫技系學會指導老師,自治性社團第二名
  20. 台中榮總醫院與中區十大院校合作研究計畫聯合成果發表會榮興計畫第一名(99.5.23)
  21. 台中榮總醫院與中區十大院校合作研究計畫聯合成果發表會榮臺計畫第二名(99.5.23)
  22. 台中榮總醫院與中區十大院校合作研究計畫聯合成果發表會大會特優論文獎(98.5.26)
  23. 台中榮總醫院與中區十大院校合作研究計畫聯合成果發表會。大會特優論文獎。(98.5.26)
  24. 台中榮總醫院與中區十大院校合作研究計畫聯合成果發表會。壁報論文佳作
  25. 中臺科技大學學術部落格競賽佳作 (2008)