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Ho,Tsing Fen

何杏棻 教授 (Tsing-Fen, Ho)

 

Job title: Professor and Chairman

Name: Tsing-Fen Ho, Ph.D.

Research expertise: Anti-inflammation, anti-cancer therapy

Emai tfho@ctust.edu.tw

Office phone number:(04) 2239-1647 #7000

 

Education

Department of Life Science, National Chung Hsing University, Taiwan

Department of Neuroscience, National Yang-Ming University, Taiwan

School of Medical Laboratory Science and Biotechnology, Taiwan

 

Professional Fields

Life Science, Apoptosis, Blood Bank

 

Courses Taught

Life Science, Apoptosis, Blood Bank, Research Methods and Laboratory

(A) SCI

  1. Ting Ting Li, Ching Wen Lou, An Pang Chen, Mong Chuan Lee, Tsing Fen Ho, Yueh Sheng Chen, Jia Horng Lin. Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds. Materials 2016; 9 (9), 793. doi: 10.3390/ma9090793 (SCI; IF: 2.728; Ranking: 35/82 (top 42.7%; polymer science)) Materials Science
  2. Jia-Horng Lin, An-Pang Chen, Ting-Ting Li, Tsing-Fen Ho, Mei-Chen Lin, Ching Wen Lou. Preparation technique and antibacterial evaluation of high-absorbent composite fabrics. Journal of Industrial Textiles 2016; 45, 915-929. (SCI; IF 1.2; Ranking: 4/22 (top 18%; Materials Science)
  3. Tsing-Fen Ho, Chia-Che Chang. A promising “TRAIL” of tanshinones for cancer therapy. Biomedicine 2015; 5 (4), 29-35.
  4. Kai-Wei Chang#, Tsing-Fen Ho# (co-first author), Yu-Chang Lin, Cheng-Ping Kuan. Development of real-time RT-PCR assays for detection and quantification of pineapple mealybug wilt-associated viruses-1. Journal of Phytopathology; Article first published online: 16 Dec 2015. Doi: 10.1111/jph.12462. (SCI; IF 0.82; Ranking: 143/200 (top 71.5%; plant sciences)) (#co-first author)
  5. Chia-Che Chang, Cheng-Ping Kuan, Jyun-Yi Lin, Jui-Sheng Lai, Tsing-Fen Ho*. Tanshinone IIA facilitates TRAIL sensitization by up-regulating DR5 through the ROS-JNK-CHOP signaling axis in human ovarian carcinoma cell lines. Chem. Res. Toxicol. 2015; 28, 1574-1583. (SCI; IF 3.529; Ranking: 10/59 (top 16.9%; chemistry & medicinal)) (*Corresponding author)
  6. Jyun-Yi Lin, Yu-Min Ke, Jui-Sheng Lai, Tsing-Fen Ho*. Tanshinone IIA enhances the effects of TRAIL by downregulating survivin in human ovarian carcinoma cells. Phytomedicine 2015; 22, 929–938. (SCI; IF 3.126; Ranking: 2/24 (top 8.3%; integrative & complementary medicine)) (*Corresponding author)
  7. 何杏棻*.生命科學新視界—以社會議題為教學設計201411月.通識在線第五十五期,49-52頁。
  8. Chia-Che Chang, Jui-Sheng Lai, Chi-Shiuan Tsai, Song-Wei Ma, Jyun-Yi Lin, Lan-Ru Huang, Chien-Hsing Lu, En-Chih Liao, Tsing-Fen Ho*. Proapoptotic and TRAIL- sensitizing constituents isolated from Salvia militiorrhiza (Danshen). J Biosci Bioeng 2013; 116, 516-523. (SCI; IF 1.884; Ranking: 39/123 (top 31.7%; food science & technology)) (*Corresponding author)
  9. Shu-Yi Yang, Hui-Min Wang, Tai-Wen Wu, Yi-Ju Chen, Jeng-Jer Shieh, Ju-Hwa Lin, Tsing-Fen Ho, Ren-Jie Luo, Chung-Yi Chen and Chia-Che Chang. Subamolide B isolated from medicinal plant Cinnamomum subavenium induces cytotoxicity in human cutaneous squamous cell carcinoma cells through mitochondrial and CHOP-dependent cell death pathways. Evid. Based Complement. Alternat. Med., 2013 (2013). doi:10.1 155/2013/630415 (SCI; IF: 4.774; Ranking: 1/22 (top 4.5%; integrative & complementary medicine)
  10. Mu-Yun Pan, Yuh-Chiang Shen, Chien-Hsing Lu, Shu-Yi Yang, Tsing-Fen Ho, Yu-Ta Peng, Chia-Che Chang. Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines. Toxicology and Applied Pharmacology 2012; 265, 325-334. (SCI; IF: 4.447; Ranking: 10/83 (top 12 %; Toxicology))
  11. Chia-Che Chang, Wei-Chuan Chen, Tsing-Fen Ho, Ho-Shing Wu, Yu-Hong Wei: Development of natural anti-tumor drugs by microorganisms. J Biosci Bioeng 2011; 111, 501-511. (SCI; IF: 1.793; Ranking: 40/128 (top 31 %; food science & technology))
  12. Tsing-Fen Ho, Yu-Ta Peng, Show-Mei Chuang, Shin-Chang Lin, Bo-Lin Feng, Chien-Hsing Lu, Wan-Ju Yu, Jo-Shu Chang, Chia-Che Chang. Prodigiosin down-regulates survivin to facilitate paclitaxel sensitization in human breast carcinoma cell lines. Toxicology and Applied Pharmacology 2009; 235, 253-260. (SCI; IF: 4.447; Ranking: 10/83 (top 12 %; Toxicology))
  13. Tsing-Fen Ho, Chieh-Ju Ma, Chien-Hsing Lu, Yo-Ting Tsai, Yu-Hong Wei, Jo-Shu Chang, Jun-Kai Lai, Pin-Ju Cheuh, Chi-Tai Yeh, Pin-Chi Tang, Jinghua Tsai Chang, Jiunn-Liang Ko, Fu-Shing Liu, Hungchen E. Yen, and Chia-Che Chang. Undecylprodigiosin selectively induces apoptosis in human breast carcinoma cells independent of p53. Toxicology and Applied Pharmacology 2007; 225, 318-328. (SCI; IF: 4.447; Ranking: 10/83 (top 12 %; Toxicology))
  14. Tsing-Fen Ho*, Biing-Shin Yang, Yao-Teng Huang, Hsieh H. TT virus infection in screened Taiwanese blood donors. Vox Sanguinis 2000;79:198-200. (SCI; IF: 2.856; Ranking: 29/68 (top 42 %; Hematology))
  15. Tsing-Fen Ho*, Biing-Shin Yang, Yao-Teng Huang, Chin-Tun Hung. Evaluation of the use of a platelet-counting tool in plateletpheresis.Vox Sanguinis 1999;76:226-230. (SCI; IF: 2.856; Ranking: 29/68 (top 42 %; Hematology)) (獲醫檢學會臨床檢驗學術獎---血液檢測類別論文獎)
  16. Tsing-Fen Ho*, Biing-Shin Yang, Yao-Teng Huang. Evaluation of six types of hematology analyzers in Taichung blood center. J Biomed Lab Sci 1998;10:129-134.
  17. Ji-Ping Wang, Tsing-Fen Ho, Ling-Chu Chang, Chien-Chih Chen. Anti-inflammatory effect of magnolol, isolated from Magnolia officinalis, on A23187-induced pleurisy in mice. J Pharm Pharmacol 1995; 47:857-860. (SCI; IF: 2.175; Ranking: 128/261 (top 49 %; Pharmacology & Pharmacy))
  18. Ji-Ping Wang, Tsing-Fen Ho, Chung-Nan Lin, Che-Ming Teng. Effect of norathyriol, isolated from Tripterospernum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn-Schmiedeberg’s Arch Pharmacol 1994; 350-90-95. (SCI; IF: 2.647; Ranking: 101/261 (top 38 %; Pharmacology & Pharmacy))
  19. Alice-Chien Chang, Tsing-Fen Ho, Nan-Chi Chang. In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans. Biochem Biophy Res Com 1990; 172: 817-823. (SCI; IF: 2.484; Ranking: 173/290 (top 60 %; Biochemistry & Molecular Biology))

(B) Patent

可提高腫瘤細胞凋亡之醫藥組合物、(何杏棻、張嘉哲)、發明第401080號、中華民國、專利權期間:自20137 11日至203146日止

(C) Conference

  1. Ju-Huei Chien, Ting-Lun Cheng, Hui-Fen Liu, Zhong-Yi Hsu, Ching-Yi Lin, Meng-Yu Kan, Shu-Cheng Liu, Chan Ping Lee, Tsing-Fen Ho*: Estimation of prevalence of acute transfusion reactions in Taiwan: a preliminary step towards to patient-focus hemovigilance. The 34th International Congress of the ISBT in 2016, Dubai.
  2. Tsing-Fen Ho*, Jyun-Yi Lin. Tanshinone IIA facilitates TRAIL sensitization through CHOP-mediated DR5 up-regulation in human ovarian cancer cells. The 8th Asia-Pacific Forum of Medical Laboratory Science in 2016, Taichung.
  3. Jyun-Yi Lin, Yu-Ting Peng, Hong-Rong Lai, Yu-Min Ke, Jui-Sheng Lai, Chia-Che Chang, Tsing-Fen Ho*: Tanshinone IIA enhances the efficacy of TRAIL against human ovary cancer cell lines. The 29th Joint Annual Conference of Biomedical Sciences, Taipei, 2014.
  4. Yu-Min Ke, Wei-Sheng Jhan, Yu-Ting Peng, Jyun-Yi Lin, Tsing-Fen Ho*The anti-tumor effect of ethnol extracts from Danshen (Salvia milltiorrhiza) Cross-strait laboratory medicine symposium in 2013.
  5. Tsing-Fen Ho*, Cheng-Ping Kuan, Chien-Hsing Lu, Jui-Sheng Lai, Song-Wei Ma, Jyun-Yi Lin, Mu-YunPan, Shu-Yi Yang, Mei-Yan Su, Jeremy J.W. Chen, Chia-Che Chang: TIIA facilitates TRAIL sensitization through ROS-mediated CHOP up-regulation in human ovarian cancer cells. 2012  轉譯醫學基因體蛋白質體之臨床應用學術研討會, 2012.
  6. Chi-Shiuan Tsai, You-Ru Sia, Mu-YunPan, Shu-Yi Yang, Mei-YanSu, Chia-Che Chang, Tsing-Fen Ho*: Tanshinone IIA facilitates TRAIL sensitization through ROS-mediated CHOP up-regulation in human ovarian cancer cells. The 27th Joint Annual Conference of Biomedical Sciences, Taipei, 2012.
  7. Jui-Sheng Lai, Song-Wei Ma, Jyun-Yi Lin, Chi-Shiuan Tsai, Chien-Hsing Lu, Chia-Che Chang, Tsing-Fen Ho*: Study of the anti-tumor effect of active components from Salvia militiorrhiza and its apoptosis. Traditional Chinese Medicine and Alternative (Herbal) Medicine, Taichung, 2011.
  8. Yu-Ta Peng, Mu-Yun Pan, Chien-Hsing Lu, Tsing-Fen Ho, Chia-Che Chang: The anticancer agent prodigiosin up-regulates activating transcription factor 3 (ATF3) to induce apoptosis. The 26th Joint Annual Conference of Biomedical Sciences, Taipei, 2011.
  9. Bo-Lin Feng, Shin-Chang Lin, Chien-Hsing Lu, Yu-Ta Peng, Chin-Hsia Wu, Yuh-Chiang Shen, Pin-chi Tang, Tsing-Fen Ho, Jo-Shu Chang, Chia-Che Chang: Essential Role of JNK and p38 MAPK in Apoptosis Induction by the Anticancer Agent Undecylprodigiosin through TRAIL- and Mitochondria-dependent Apoptotic Pathways. The 25th Joint Annual Conference of Biomedical Sciences, Taipei, 2010.
  10. Tsing-Fen Ho, Chien-Hsing Lu, Wan-Ju Yu, Chia-Che Chang: Gene expression profiles predict prodigiosin molecular mechanism by cDNA microarray. 2010年中區十大院校暨台中榮民總醫院合作研究計畫聯合成果發表會-榮台計畫壁報論文第二名
  11. Bo-Lin Feng, Chien-Hsing Lu, Yu-Ta Peng, Chin-Hsia Wu, Yuh-Chiang Shen, Pin-chi Tang, Tsing-Fen Ho, Jo-Shu Chang, Chia-Che Chang: Essential Role of JNK and p38 MAPK in Apoptosis Induction by the Anticancer Agent Undecylprodigiosin through TRAIL- and Mitochondria-dependent Apoptotic Pathways. 2010年台中榮總醫院與中區十大院校合作研究計畫聯合成果發表會-榮興計畫壁報論文第一名
  12. Tsing-Fen Ho, Yu-Ta Peng, Show-Mei Chuang, Shin-Chang Lin, Bo-Lin Feng, Chien-Hsing Lu, Wan-Ju Yu, Jo-Shu Chang, Chia-Che Chang: The role of survivin in prodigiosin-induced apoptosis in breast cancer cells. 2009年台中榮總醫院與中區十大院校合作研究計畫聯合成果發表會-壁報論文佳作。
  13. Tsing-Fen Ho, Yu-Ta Peng, Show-Mei Chuang, Shin-Chang Lin, Bo-Lin Feng, Chien-Hsing Lu, Wan-Ju Yu, Jo-Shu Chang, Chia-Che Chang: Prodigiosin enhances paclitaxel drug efficacy against human breast carcinoma cell lines. The 24th Joint Annual Conference of Biomedical Sciences, Taipei, 2009.
  14. Tsing-Fen Ho, Yu-Ta Peng, Show-Mei Chuang, Shin-Chang Lin, Bo-Lin Feng, Chien-Hsing Lu, Wan-Ju Yu, Jo-Shu Chang, Chia-Che Chang: The role of survivin in prodigiosin-induced apoptosis in breast cancer cells. The 23th Joint Annual Conference of Biomedical Sciences, Taipei, 2008.
  15. Tsing-Fen Ho, Yo-Ting Tsai, Yu-Hong Wei, Jo-Shu Chang, Chieh-Ju Ma, Hungchen E. Yen, Chia-Che Chang: Selective proapoptotic effect of undecylprodigiosin on human breast cancer cell lines. The 22th Joint Annual Conference of Biomedical Sciences, Taipei, 2007.

(D) Book and article

  1. Tsing-Fen HoLife Science ISBN 9789869037334003202015.2。智翔。
  2. 李意旻、Tsing-Fen HoLabtory of Anatomy and Physiology ISBN 9789569037341001602015.3。智翔。
  3. Tsing-Fen Ho.生命科學新視界—以社會議題為教學設計 2014. 11.通識在線第五十五期,p. 49-52
  4. Tsing-Fen Ho2008.8The underlying mechanisms of prodigininesThesis of doctor degree
  5. 李玉菁、何杏棻、黃玉琪、陳秋媛、李意旻、阮大盛、徐玉華。2000 再版。人體解剖學。文京
  6. 李意旻、李玉菁、何杏棻、黃玉琪、林靜瑩。2000 再版。解剖生理學實驗。文京。

Research Plan (擔任計畫主持人)

  1. The underlying mechanisms of the TRAIL sensitization by tanshinone IIA  (MOST105-2313-B-166-001) 2016.8.1~2017.7.31
  2. Elucidate the mechanism of down-regulating survivin by tanshinone IIA in ovarian cancer cells (CTU104-P-16) 104.5.19~104.10.15
  3. 探討吲哚化合物對結腸直腸癌抗癌作用的影響因子 (TCVGH-CTUST1037702) 103.1.1~103.12.31
  4. Study the role of survivivn in tanshinone IIA sensitized TRAIL (TCVGH-CTUST1037704) 103.1.1~103.12.31
  5. Underlying mechanisms of tanshinone IIA-induced TRAIL sensitization in TRAIL resistant (CTU102-P-17) 102.1.1~102.12.31
  6. Study the role of survivivn in tanshinone IIA-induced apoptosis (TCVGH-CTUST1027704) 102.1.1~102.12.31
  7. Study of the anti-tumor effect of active components from herbal medicine cultured in Taiwan and its underlying mechanisms (R100504R0050017-產學-101) 101.4.10~101.7.31
  8. Study of the anti-tumor effect of active components from Salvia militiorrhiza and its underlying mechanisms (CTU99-TARI-001) 99.7.1~100.12.31