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分類清單
陳世順

陳世順 教授 (Chen,Shih Shun)

 

學歷

國防大學醫學院  生命科學研究所  博士

國防醫學院   微生物及免疫學研究所 碩士

中國醫藥學院    醫學技術學系   學士

專長

分子腫瘤學、病毒學、基因轉殖動物、微生物及免疫學、醫學檢驗

任教科目

臨床血液學、分子病毒學、臨床血清免疫學、生物製劑學、分子生物學技術、分子診斷技術、微生物及免疫學、腫瘤生物學

研究成果

(A) SCI 期刊論文

  1. Meng-Liang Lin*, Shih-Shun Chen, Ren-Yu Huang, Yao-Cheng Lu, Yu-Ren Liao, M. Vijaya Bhaskar Reddy, Chuan-Chun Lee, Tian-Shung Wu. 2014. Suppression of PI3K/Akt signaling by synthetic bichalcone analog TSWU-CD4 induces ER stress- and Bax/Bak-mediated apoptosis of cancer cells. Apoptosis 2014 Sep 3. [Epub ahead of print] (SCI, Impact factor:3.614, Subject Categories: BIOCHEMISTRY & MOLECULAR BIOLOGY (Ranking:2013:100/291=34.36%))
  2. Meng-Liang Lin, Yao-Cheng Lu, Hung-Yi Chen, Chuan-Chun Lee, Jing-Gung Chung, and Shih-Shun Chen*. 2014. Suppressing the formation of lipid raft-associated Rac1/PI3K/Akt signaling complexes by curcumin inhibits SDF-1a-induced invasion of human esophageal carcinoma cells. Mol Carcinog. 53(5):360-379 (SCI, Impact factor:4.770, Subject Categories: ONCOLOGY (Ranking:2013:43/202=21.28%) (corresponding author) (CTU100-P11)
  3. Vijaya Bhaskar Reddy Mopur, Shih-Shun Chen, Meng-Liang Lin, Hsiu-Hui Chan, Ping-Chung Kuo, and Tian-Shung Wu*. 2011. Preparation of a series of novel bichalcones linked with a 1,4-dimethylenepiperazine moiety and examination of their cytotoxicity. Chem Pharm Bull (Tokyo). 59(12):1549-54. (SCI, Impact Factor:1.375, Subject Categories: CHEMISTRY, MULTIDISCIPLINARY (Ranking:2013:76/148=51.35%))
  4. Meng-Liang Lin, Yao-Cheng Lu, Hong-Lin Su, Hsin-Ting Lin, Chuan-Chun Lee, Shang-En Kang, Tan-Chen Lai, Jing-Gung Chung, and Shih-Shun Chen*. 2011. Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8–mediated p53-independent apoptosis of human carcinoma cells. J Cell Biochem. 112(4):1176-1191. (SCI, Impact Factor:3.368, Subject Categories: BIOCHEMISTRY & MOLECULAR BIOLOGY (Ranking:2013:107/291=36.77%)) (corresponding author) (TCVGH-CTUST987715)
  5. Hui-Ying Hsu, Jai-Sing Yang, Kung-Wen Lu, Chun-Shu Yu, Su-Tze Chou, Jen-Jyh Lin, Ya-Yin Chen, Meng-Liang Lin, Fu-Shin Chueh, Shih-Shun Chen, and Jing-Gung Chung. 2010. An experimental study on the antileukemia effects of gypenosides in vitro and in vivo. Integr Cancer Ther. 10(1):101-112. (SCI, Impact Factor:2.014, Subject Categories: INTEGRATIVE & COMPLEMENTARY MEDICINE (Ranking:2013:7/22=31.82%)
  6. Meng-Liang Lin, Yao-Cheng Lu, Jing-Gung Chung, Shyang-Guang Wang, Hsin-Ting Lin, Shang-En Kang, Chih-Hsin Tang, Jiunn-Liang Ko, and Shih-Shun Chen*. 2010. Down-regulation of MMP-2 through the p38 MAPK-NF-κB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion. Mol Carcinog. 49(9):783-797. (SCI, Impact factor:4.770, Subject Categories: ONCOLOGY (Ranking:2013:43/202=21.28%) (corresponding author) (CTU-98-LS-001)
  7. Meng-Liang Lin, Yao-Cheng Lu, Jing-Gung Chung, Yi-Chen Li, Shyang-Guang Wang, Sue-Hwee NG, Chia-Yin Wu, Hong-Lin Su, and Shih-Shun Chen*. 2010. Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway. Cancer Letters 291(1):46-58. (SCI, Impact Factor: 5.016, Subject Categories: ONCOLOGY (Ranking:2013:33/202=16.34%) (corresponding author) (CTU-98-LS-001)
  8. Meng-Liang Lin, Jinng-Gung Chung, Yao-Cheng Lu, Chiou-Ying Yang, and Shih-Shun Chen*. 2009. Rhein inhibits invasion and migration of human nasopharyngeal carcinoma cells in vitro by down-regulation of matrix metalloproteinases-9 and vascular endothelial growth factor. Oral Oncol. 45:531-537. (SCI, Impact Factor: 3.029, Subject Categories: ONCOLOGY (Ranking:2013:80/202=39.60%) (DENTISTRY, ORAL SURGERY & MEDICINE (Ranking:2013:5/82=6.098%))(corresponding author)
  9. Meng-Liang Lin, Shih-Shun Chen, Yao-Cheng Lu, Rui-Yue Liang, Yung-Tsuan Ho, Chiou-Ying Yang, and Jinng-Gung Chung*. 2007. Rhein induces apoptosis through induction of endoplasmic reticulum stress and Ca++-dependent mitochondrial death pathway in human nasopharyngeal carcinoma cells. Anticancer Res. 27(5A):3313-3322. (SCI, Impact Factor: 1.872, Subject Categories: ONCOLOGY (Ranking:2013:145/202=71.78%)
  10. Ying-Hue Lee, Mark A. Magnuson, Vijayakumar Muppala, and Shih-Shun Chen. 2003. Liver-specific reactivation of the inactivated Hnf-1a gene: elimination of liver dysfunction to establish a mouse MODY3 model. Mol. Cell. Biol. 23: 923-932. (SCI) (SCI, Impact factor:5.036, Subject Categories: BIOCHEMISTRY & MOLECULAR BIOLOGY (Ranking:2013:55/291=18.9%))
  11. Shih-Shun Chen, Pi-Chu Chang, Yu-Wen Cheng, Feng-Mei Tang, and Young-Sun Lin*. 2002. Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. EMBO J 21: 4491-4499. (SCI) (SCI, Impact factor:10.748, Subject Categories: BIOCHEMISTRY & MOLECULAR BIOLOGY (Ranking:2013:15/291=5.15%))
  12. Letetia C. Jones, Meng-Liang Lin, Shih-Shun Chen, Utz Krug, Wolf-K. Hofmann, Stephen Lee, Ying-Hue Lee, and H. Phillip Koeffler*. 2002. Expression of C/EBP-Beta from the C/ebp-alpha gene locus is sufficient for normal hematopoiesis in vivo. Blood 99: 2032-2036. (SCI) (SCI, Impact factor:9.775, Subject Categories: HEMATOLOGY (Ranking:2013:2/68=2.94%))
  13. Shih-Shun Chen, Jin-Feng Chen, Peter F. Johnson, Vijayakumar Muppala, and Ying-Hue Lee*. 2000. C/EBPb, when expressed from the C/ebpa gene locus, can functionally replace C/EBPa in liver but not in adipose tissue. Mol. Cell. Biol. 20: 7292-7299. (SCI) (SCI, Impact factor:5.036, Subject Categories: BIOCHEMISTRY & MOLECULAR BIOLOGY (Ranking:2013:55/291=18.9%))
  14. Ching-Liang Chu, Shih-Shun Chen, Tzong-Shoon Wu, Szu-Cheng Kuo, and Nan-Shih Liao*. 1999. Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing gamma delta T cell receptor in mice. J. Immunol. 162: 1896-1903. (SCI) (SCI, Impact factor:5.362, Subject Categories: IMMUNOLOGY (Ranking:2013:24/144=16.67%))
  15. Chi-Long Lin, Jin-Ching Lee, Shih-Shun Chen, Harry Alan Wood, Ming-Liang Lin, Chih-Fen Li, and Yu-Chan Chao*. 1999. Persistent Hz-1 virus infection in insect cells: evidence for insertion of viral DNA into host chromosomes and viral infection in a latent status. J. Virol. 73: 128-139. (SCI) (SCI, Impact factor:4.648, Subject Categories: VIROLOGY (Ranking:2013:7/32=21.88%))
  16. Yu-Chan Chao*, Song-Tay Lee, Ming-Chuan Chang, Hong-Hwa Chen, Shih-Shun Chen, Tzong-Yuan Wu, Fu-Hwa Liu, Err-Leih Hsu, and Roger F. Hou. 1998. A 2.9-kb non-coding nuclear RNA function in the establishment of persistent Hz-1 virus infection. J. Virol. 72: 2233-2245. (SCI) (SCI, Impact factor:4.648, Subject Categories: VIROLOGY (Ranking:2013:7/32=21.88%))
  17. Yi-Ling Lin*, Li-Kuang Chen, Ching-Len Liao, Chia-Tsui Yeh, Shiou-Hwa Ma, Ji-Ling Chen, Yue-Ling Huang, Shih-Shun Chen, and Hsien-Yuan Chiang. 1998. DNA immunization with Japanese encephalitis virus nonstructural protein NS1 elicits immunity in mice. J. Virol. 72: 191-200. (SCI) (SCI, Impact factor:4.648, Subject Categories: VIROLOGY (Ranking:2013:7/32=21.88%))

(B) 研討會論文

  1. Meng-Liang Lin, Hung-Yi Chen, Yao-Cheng Lu, Shang-En Kang, Chuan-Chun Lee, Hsin-Ting Lin, Sue-Hwee NG, Jing-Gung Chung, Hsiang-Ju Huang, Shih-Shun Chen*. (March 12-13, 2011) Suppressing the formation of lipid raft-associated CXCR4-Rac-1 signaling complex by curcumin inhibits SDF-1-induced invasion of human esophageal carcinoma cells. (P499 Poster) (corresponding author)26屆生物醫學聯合學術年會
  2. Yao-Cheng Lu, Meng-Liang Lin, Hong-Lin Su, Wei-Hsiu Chen, Hsin-Ting Lin, Chuan-Chun Lee, Shang-En Kang, Ching-Len Liao, and Shih-Shun Chen*. (February 10-12, 2011) Lipid rafts involved in formation of flavivirus replication complex. (P221 Poster) (corresponding author) Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology第十九屆細胞及分子生物新知研討會
  3. Meng-Liang Lin, Yao-Cheng Lu, Hong-Lin Su, Hsin-Ting Lin, Chuan-Chun Lee, Shang-En Kang, Jing-Gung Chung, and Shih-Shun Chen*. (February 10-12, 2011) Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8–mediated p53-independent apoptosis of human carcinoma cells. (P283 Poster) (corresponding author) Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology第十九屆細胞及分子生物新知研討會
  4. Meng-Liang Lin, Yao-Cheng Lu, Hung-Yi Chen, Jiunn-Min Wang, Li-Jiau Huang, Sheng-Chu Kuo*, and Shih-Shun Chen*. (May 23, 2010) Anti-tumor Activity of CHM-1 Against Human Neuroblastoma Cells In Vitro. (TCVGH-CTUST987714) (corresponding author) 台中榮民總醫院與中區各大學98年度合作研究計畫聯合成果發表會論文壁報獎第一名
  5. Meng-Liang Lin, Yao-Cheng Lu, Hong-Lin Su, Hsin-Ting Lin, Shang-En Kang, Chuan-Chun Lee, Jing-Gung Chung, Pen-Tung Liao, Hi-I Huang, Fu-Yi Lai, and Shih-Shun Chen*. (March 27-28, 2010) Involvement of Caspase-8-Mediated Activation of ERK and Mitochondrial Death Pathways in Aloe-Emodin-Induced p53-Independent Apoptosis of Human Pharyngeal Squamous Carcinoma Cells (P250 Poster) (corresponding author) 25屆生物醫學聯合學術年會優秀看板論文壁報獎得獎
  6. Chuan-Jun Lee, Meng-Liang Lin, Jing-Gung Chung, Shih-Shun Chen*. (March 16, 2010 International Conference Hall) The effect of Galangin on the Growth and Apoptosis of Nasopharyngeal Carcinoma Cell Lines (P36 Poster) 3th Asia University and China Medical University Joint Conference on Biotechnology
  7. Wei-Hsiu Chen, Meng-Liang Lin, Yi-Ling Lin, Ching-Len Liao*, and Shih-Shun Chen*. (March 29-30, 2008) Lipid Rafts Involved in the Formation of Japanese Encephalitis Virus Replication Complex (P787 Poster) 23屆生物醫學聯合學術年會(corresponding author)
  8. Yao-Cheng Lu, Meng-Liang Lin, Yi-Ling Lin and Ching-Len Liao*, and Shih-Shun Chen*. (March 29-30, 2008) A Single Amino Acid Substitution in NS2A of Japanese Encephalitis Virus Demonstrates the Essential Roles for NS1’ in the Early Stage of Virus Replication and Virus Virulence in Mice (P799 Poster). 23屆生物醫學聯合學術年會(corresponding author)
  9. Meng-Liang Lin, Chia-Yin Wu, Yao-Cheng Lu, Sue-Hwee NG, Chao-Chin Chang, Jing-Gung Chung, and Shih-Shun Chen*. (March 29-30, 2008) Down-Regulation of Matrix Metalloproteinases-2 and Vascular Endothelial Growth Factor by Aloe-emodin Leads to the Inhibition of Nasopharyngeal Carcinoma Cell Invasion and Migration (P765 Poster) 23屆生物醫學聯合學術年會(corresponding author)
  10. Chao-Chin Chang, Yao-Cheng Lu, Yuan-Cheng Hsu, Hong-Lin Su, Jing-Gung Chung, Meng-Liang Lin*, and Shih-Shun Chen*. (November 16-17, 2007) Activation of p53 and Mitochondrial Apoptosis Pathway by Aloe-Emodin in Human Pharyngeal Carcinoma Cells (3-12 Poster) 第一屆國際癌症學術研討會(The 1st International Cancer Symposium in CMU&H) (corresponding author)
  11. Meng-Liang Lin, Jing-Gung Chung, Yao-Cheng Lu, Chiou-Ying Yang, and Shih-Shun Chen*. (November 16-17, 2007) Rhein Inhibits Invasion and Migration of Human Nasopharyngeal Carcinoma Cells In Vitro by Down-Regulation of Matrix Metalloproteinases-9 and Vascular Endothelial Growth Factor (3-7 Poster) 第一屆國際癌症學術研討會(The 1st International Cancer Symposium in CMU&H) (corresponding author)

(C)專書及專書論文 

1. Shih-Shun Chen. Carcinogenesis, Diagnosis, and Molecular Targeted Treatment for Nasopharyngeal Carcinoma, ISBN 978-953-307-867-0, A Book Chapter in Carcinogenesis, Diagnosis, and Molecular Targeted Treatment for Nasopharyngeal Carcinoma, Edited by Dr. Shih-Shun Chen , pages 199-236, InTech - Open Access Publisher , 2012